CHRP-2 growth hormone CAS 158861-67-7

Ghrp2 is a synthetic ghrelin analogue. Like ghrelin, it stimulates release of endogenous from somatotropes in the anterior pituitary; also like ghrelin, it is synergistic with endogenous releasing-ormone (GHRH) as well as with synthetic GHRH analogues such as Sermorelin or GRF(1-29). Whereas GHRP2 and other ghrelin analogues increase the number of somatotropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or somatotrope by other means. Unlike ghrelin, GHRP2 is not lipogenic meaning it does not induce fat storage. While ghrelin has a very important role in hunger, GHRP2 as an analog of ghrelin does not increase appetite significantly. GHRP2 is synergistic with GHRH due to secondary actions on hypothalamic neurons. The quantity of GH released by a living mammal to which GHRP2 and GHRH are administered exceeds the combined release of each compound when measured when taken alone.